Legend®
Legend® (hyaluronate sodium) is the only FDA approved I.V. and intra-articular therapy to treat equine non-infectious synovitis associated with osteoarthritis. "Legend is pure hyaluronate sodium, the same glycosaminoglycan present in normal joint fluid. Legend is produced by a patented biofermentation process, resulting in such purity that it can be given intravenously for immediate bioavailability.
Key Benefits
Legend, because of its unique purity, can be given intra-articularly or intravenously. I.V. administration provides the following advantages:
- Safety
- No need to invade the joint with a needle, risking bacterial entrance, physical trauma to joint tissues or intra-articular injection reactions.
- Safety in breeding animals has not been determined.
- Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- For use only in horses. Do not use in horses intended for human consumption.
- Convenience
- No shaving or surgical preparation of the joint.
- IV administration to treat multiple joints.
- Available in a larger, 20mL Multi Dose vial for Intravenous use only.
- Efficacy
- Proven to decrease inflammation and destructive enzymes associated with inflammation.1
- Rapid onset of action. I.V. administration helps ensure a quick onset of action resulting in a rapid decrease in inflammation.
- Applications
- Legend 2mL, For Intravenous and Intra-Articular use
- Legend 4mL, For Intravenous use only
- Legend Multi 20mL, For Intravenous use only
The intra-articular safety of Legend Multi dose with benzyl alcohol has not been determined.
Footnotes
- Kawcak, C.E., Frisbie, D.D., Trotter, G.W., McIlwraith, C.W., Gillette, S.M., Powers, B.E., Walton, R.M.: Effects of intravenous administration of hyaluronate sodium on carpal joins in exercising horses after arthroscopic surgery and osteochondral fragmentation. AJVR. Vol, 58, No. 10, October 1997.