Dog and cat enjoying the outdoors because Advantage Multi® protects against dirofilaria immitis, intestinal worms and fleas.

Experience the Many Layers of Advantage Multi® (imidacloprid + moxidectin)

Multilayered heartworm, flea and intestinal parasite protection with one simple, monthly dose.

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Why Choose Advantage Multi®

Icon of dirofilaria immitis.

Heartworm disease prevention that works all month long

Icon of a flea.

Kills fleas through contact so they don’t have to bite to die

Icon of intestinal worms.

Treats and controls roundworms, hookworms and whipworms in dogs and roundworms and hookworms in cats for deep, broad-spectrum coverage

Icon of transdermal solution being applied over the skin and coat of a pet.

The Power of a Transdermal Solution

Even pets who don’t love oral medication get the protection they need, as moxidectin is quickly absorbed through the skin while imidacloprid spreads over the skin and coat. But the benefits don’t stop there.

Heartworm prevention that works all month long
Like all heartworm prevention products, Advantage Multi® works backward to clear tissue stages of heartworms acquired during the previous month. It also works forward§ by killing newly acquired heartworm larvae all day, every day, all month long.1,2 This prevents the establishment of a heartworm infection because newly deposited larvae don’t grow or migrate in the dog between doses.

Kill Multiple Worms at Multiple Stages

Most products only cover adult worms.* Advantage Multi® delivers broad-spectrum intestinal parasite coverage to protect pets from multiple life stages of the most common intestinal parasites.

Advantage Multi® for Dogs

Dogs Advantage Multi®Advantage Multi® logo ProHeart® 6/12** Simparica Trio Trifexis® Sentinel® Spectrum Interceptor® Plus Revolution® Heartgard® Plus
HEARTWORMS YES YES YES YES YES YES YES YES
Microfilaria YES NO NO NO NO NO NO NO
FLEAS YES NO YES YES YES NO YES NO
SARCOPTIC MANGE YES NO NO NO NO NO YES NO
EAR MITES NO NO NO NO NO NO YES NO
ROUNDWORMS                
T. canis adults YES NO YES YES YES YES NO YES
T. canis immature adults NO NO YES NO NO NO NO NO
T. canis L4 YES NO NO NO NO NO NO NO
T. leonina YES NO YES YES YES YES NO YES
HOOKWORMS                
A. caninum adults YES YES YES YES YES YES NO YES
A. caninum immature adults YES NO NO NO NO NO NO NO
A. caninum L4 YES YES NO NO NO NO NO NO
U. stenocephala adults YES YES YES NO NO NO NO YES
U. stenocephala immature adults YES NO NO NO NO NO NO NO
U. stenocephala L4 YES YES NO NO NO NO NO NO
A. braziliense NO NO NO NO NO NO NO YES
WHIPWORMS                
T. vulpis YES NO NO YES YES YES NO NO
TAPEWORMS NO NO NO NO YES YES NO NO
TICKS NO NO YES NO NO NO YES NO

 

*Based on label comparisons for intestinal parasites.
**ProHeart® 6 and ProHeart® 12 are indicated for the treatment of existing larval and adult hookworm (Ancylostoma caninum and Unciaria stenocephala) infections.

Advantage Multi® for Cats*

 

 

Cats

Advantage Multi®Advantage Multi® logo

Revolution® Plus Bravecto® Plus Interceptor® Heartgard®
FLEAS YES YES YES NO NO
HEARTWORMS YES YES YES YES YES
EAR MITES YES YES NO NO NO
ROUNDWORMS          
T. cati adults YES YES YES YES NO
T. cati immature adults NO NO YES NO NO
T. cati L4 YES NO YES NO NO
HOOKWORMS          
A. tubaeforme adults YES YES YES YES YES
A. tubaeforme immature adults YES NO YES NO NO
A. tubaeforme L4 YES NO YES NO NO
A. braziliense adults NO NO NO NO YES
A. braziliense immmature adults NO NO NO NO YES
TICKS NO YES YES NO NO

*Based on label comparisons for intestinal parasites.

More about Advantage Multi®

Fleas don’t have to bite to die

When Advantage Multi® is applied, imidacloprid spreads across the skin and coat and works through contact. It targets the nicotinic acetylcholine receptors on fleas, paralyzing and killing these nasty parasites — no biting necessary. This is unlike oral preventives, which work through the bloodstream, requiring fleas to bite and blood feed before dying.

Transdermal moxidectin has an extended half-life*

When applied transdermally, moxidectin concentrates in the fatty tissue, slowly releasing into the bloodstream, resulting in a long half-life.

Transdermal moxidectin has an extended half-life longer than ivermectin, mibemycin oxime and selamectin.

Transdermal moxidectin has an extended half-life longer than eprinomectin and selamectin.

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Make it easy on your patients — whether they're a 50-pound dog or a 5-pound cat. Give them the transdermal solution that protects against multiple parasites at once.

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Help Your Clients See the Beauty of Multilayered Protection

Advantage Multi® is making it easier to help educate your clients on the value of multilayered heartworm, flea and IP protection.

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Make it easy on your patients — whether they're a 50-pound dog or a 5-pound cat. Give them the transdermal solution that protects against multiple parasites at once.

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Advantage Multi® for dogs and cats package shots.

Product Label | MSDS

§Forward protection from heartworm infection means that after a single dose of Advantage Multi®, blood levels of moxidectin are continuously at or above the concentration required to kill newly acquired heartworm larvae and are maintained between continued monthly administration of these products. 

1Bowman DD, Ohmes CM, Hostetler JA, et al. (2017). Efficacy of 10% imidacloprid + 2.5% moxidectin topical solution (Advantage Multi® for Dogs) for the prevention of heartworm disease and infection all month long. Parasit Vectors. 10(2):59-64.

2Bowman DD, Ohmes CM, Bradford M, et al. (2018). Efficacy of Advantage Multi® for Cats for the prevention of heartworm disease and infection all month long. In: Proceedings. American Association of Veterinary Parasitologists. 63rd Annual Meeting. July 14-17, 2018. Denver, CO.

3Kojima K, Yamamoto K, Katae H, et al. (1987). Bioavailability of oral ivermectin in dogs. Jpn J Vet Sci. 49(5):899-900.

4SENTINEL® Spectrum [Summary of Product Characteristics]. Frimley, Camberley, Surrey, UK: Novartis Animal Health UK Ltd.; May 2008 revision.

5Sarasola P, Jernigan AD, Walker DK, et al. (2002). Pharmacokinetics of selamectin following intravenous, oral and topical administration in cats and dogs. J Vet Pharmacol Therap. 25(4): 265-272.

6Data on file. Bayer, Shawnee Mission, KS.

7Kvaternick V, Kellermann M, Knaus M, et al. (2014). Pharmacokinetics and metabolism of eprinomectin in cats when administered in a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel. Vet Parasitol. 202:2-9.

CAUTION: Advantage Multi® is only available from a licensed veterinarian. Dogs: WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application, ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with the application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings and Adverse Reactions for more information.) Cats: Do not use on sick, debilitated, or underweight cats. Avoid oral ingestion.

©2020 Bayer, Shawnee Mission, KS 66201.
Bayer, the Bayer Cross and Advantage Multi are registered trademarks of Bayer. All other trademarks are the property of their respective owners.
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