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Baytril® Otic (enrofloxacin/silver sulfadiazine) Emulsion packaging and bottles with ear dropper tips.

Baytril® Otic (enrofloxacin/silver sulfadiazine) Antibacterial-Antimycotic Emulsion



Canine otitis externa



Bacteria and yeast




Active Ingredient

Active Ingredients:

Enrofloxacin, silver sulfadiazine


Baytril® Otic (enrofloxacin/silver sulfadiazine) Antibacterial-Antimycotic Emulsion is a topical, nonirritating, water-based emulsion that is easy to administer. The product uniquely features two different antimicrobials with activity against difficult pathogens such as Pseudomonas. Silver sulfadiazine (SSD) modifies and weakens cell membranes and walls, while enrofloxacin attacks DNA gyrase to interfere with bacterial DNA replication. SSD also provides activity against yeast. 

CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. Federal law prohibits the extra label use of this drug in food-producing animals.

PRECAUTIONS: The safe use of Baytril® Otic in dogs with perforated tympanic membranes has not been evaluated. Therefore, the integrity of the tympanic membrane should be evaluated before administering this product. If hearing or vestibular dysfunction is noted during course of treatment, discontinue use of Baytril® Otic.

CONTRAINDICATIONS: Baytril® Otic is contraindicated in dogs with suspected or known hypersensitivity to quinolones and/or sulfonamides.


  • Canine otitis externa
  • Dermatology
  • Infections


What are the active ingredients in Baytril® Otic?

Each mL contains:

  • 5 mg enrofloxacin
  • 10 mg silver sulfadiazine (SSD)
What are the dosing and frequency guidelines for Baytril® Otic?

Shake well before each use. 

Tilt patient’s head so that the affected ear is presented in an upward orientation. Administer a sufficient quantity of Baytril® Otic to coat the aural lesions and the external auditory canal. As a general guide, administer 5 to 10 drops per treatment to dogs weighing 35 lbs. or less, and 10 to 15 drops per treatment in dogs weighing more than 35 lbs. Following treatment, gently massage the ear to ensure complete and uniform distribution of the medication throughout the external ear canal. After initial application, clients can apply twice daily for up to 14 days.

How is Baytril® Otic available?

Purchased in multiples of 12: supplied as 15 mL bottles with dropper tip and extended tip closure, in boxes of 12 bottles each.

Baytril is a registered trademark of Bayer.

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