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Two active ingredients* work two different ways

Imidacloprid 10%

  • Distributed in the skin's waterproof lipid layer, the hair follicles and the sebaceous glands1

  • Kills fleas through contact

  • Fleas don't have to bite to die

Moxidectin 2.5%

  • Absorbed through the skin and distributed through the tissues

  • Highly lipophilic with quick absorption and dissemination throughout the body2

  • Deposits in fat tissues act as a drug reservoir2

*Feline product is formulated with 10% imidacloprid and 1% moxidectin.

1. Chopade H, Eigenberg D, Solon E, et al. (2010). Skin distribution of imidacloprid by microautoradiography after topical administration to beagle dogs. Vet Ther. 11(10):E1-10.
2. Vanapalli SR, Hung Y, Fleckenstein L, et al. (2002). Pharmacokinetics and dose proportionality of oral moxidectin in beagle dogs. Biopharm Drug Dispos. 23(7):263-272.

Product Label

PRECAUTIONS: The safe use of Advantage Multi® for Dogs (imidacloprid + moxidectin) has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs body weight.


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