Illustrative of cross-linked HA at the wound site
Wound healing, a complex biological interaction
Cutaneous wound healing requires biological coordination of complex interactions among various cells, cytokines and the extracellular matrix in damaged tissue. Our knowledge of the process of wound healing has increased greatly over the years, including the role played by hyaluronic acid (HA). Hyaluronic acid aids in wound repair by binding to specific cell-surface receptors promoting fibroblast migration. It also works to regulate inflammation and promote collagen deposition.1
Cross-linking technology helps support the therapeutic performance of hyaluronic acid
Cross-linked hyaluronic acid technology helps create an environment conducive to cell migration during normal re-epithelialization.2 Cross-linking also imparts viscosity properties suitable for eye care applications.
Convenient skin and eye care products
• Remend® Corneal Repair Gel helps to support the natural healing process in dogs' and cats' injured corneas. Does not contain an antibiotic or steroid.
• Remend® Eye Lubricating Drops supports hydration and lubrication of the eyes to minimize dryness.
• Remend® Wound Spray Gel supports the natural healing process of minor wounds (lacerations, scrapes and abrasions) of the skin on dogs and cats.
1. Theoret CL. (2009). Tissue Engineering in Wound Repair: The three “R”s – Repair, Replace, Regenerate. Veterinary Surgery. 38(8):905-913.
2. Vanderhooft JL. (2009). Rheological Properties of Cross-Linked Hyaluronan-Gelatin Hydrogels for Tissue Engineering.
Macromol Biosci. 9:20-28.
3. Williams, DL and Mann, BK. (2013) A Crosslinked HA-Based Hydrogel Amerliorates Dry Eye Symptoms in Dogs. International Journal of Biomaterials, Vol. 2013, Article ID 460437, 8 pages, doi:10.1155/2013/460437.
Companion animal practitioners now have a line of products that support the natural healing processes of dogs' and cats' superficial skin wounds and corneal ulcers.
The cross-linking technology creates a scaffolding matrix to support a healing environment conducive to cell migration and tissue regrowth.2
Remend® Corneal Repair Gel and Eye Lubricating Drops are affordable and easy to use. In some patients, twice-daily administration may be appropriate.3